Bladder cancer is a disease in which cancer cells grow in the bladder. The bladder, which is located in the lower abdomen, is a hollow organ with flexible muscular walls. Its primary function is to store urine until a person is ready to urinate.

Cancer occurs when cells in the body (in this case, bladder cells) divide without control or order. Normally, cells divide in a regulated manner. If cells keep dividing uncontrollably when new cells are not needed, a mass of tissue, called a growth or tumor, forms. The term cancer refers to malignant tumors, which can invade nearby tissue and spread to other parts of the body. A benign tumor does not invade or spread.

There are three main types of cancer that affect the bladder. They are named for the type of cell that becomes cancerous:

• Transitional cell (urothelial) carcinoma–accounts for more than 90% of bladder cancers

• Squamous cell carcinoma–accounts for about 4% of bladder cancers

• Adenocarcinoma–accounts for about 1%-2% of bladder cancers

Causes

The cause of bladder cancer is unknown. However, several risk factors have been identified.

Risk Factors

A risk factor is something that increases your chances of getting a disease or condition.

The following factors increase your chances of developing bladder cancer:

• Smoking

• Increasing age: the majority of people with bladder cancer are between 65-85 years old

• Occupation: due to occupational exposures to certain substances. Occupations at risk include:

• • Rubber, leather, and textile workers

• • Painters

• • Hairdressers

• • Machinists

• • Printers

• • Truck drivers

• • Petroleum industry workers

• Race: White

• Sex: Male

• Genetics

• Chronic bladder inflammation or infection (eg, schistosomiasis, an infection caused by a parasitic worm)

• Personal or family history of bladder cancer

• Chemotherapeutic drugs: cyclophosphamide and ifosfamide

• Exposure to arsenic

• Radiation treatment of the pelvis

• Bladder birth defects

• Chemicals (nitrosamines, benzidine, etc.)

• Urinary stones for many years

• Indwelling catheter for many years

• Bladder diverticuli

• Metastasis from primary cancer

Symptoms

Symptoms include:

• Blood in the urine (hematuria)

• Frequent urination, or feeling the need to urinate without being able to

• Painful urination

• Lower back pain

• Weight loss, bone or abdominal pain in advanced cases

These symptoms may be caused by other less serious health conditions, such as bladder stones or infection. If you are experiencing any of these symptoms, see your physician.

Diagnosis

Your doctor will ask about your symptoms and medical history, and perform a physical exam. During the exam, your doctor will feel the abdomen and pelvis for abnormalities. The physical exam may include a rectal or vaginal exam.

Tests include:

Urine Cytology–a sample of urine is examined under a microscope to look for cancerous or precancerous cells

Urine Culture–a sample of urine is cultured to look for signs of infection (ie, bacteria)

Cystoscopy–a procedure in which a doctor looks into the bladder through the urethra using a cytoscope (a slender tube with a lens and light)

Intravenous Pyelogram (IVP)–x-rays of the bladder, kidneys, and ureters taken after dye is injected into the bloodstream

CT Scan–a type of x-ray that uses a computer to make pictures of the inside of the bladder and surrounding structures

Magnetic Resonance Imaging (MRI) Scan–a test that uses magnetic waves to make pictures of the inside of the bladder and surrounding structures

Ultrasound–a test that uses sound waves to examine the bladder

Bone Scan–a type of x-ray that uses a computer to make pictures of the bone if metastases suspected

Biopsy–removal of a sample of bladder tissue to test for cancer cells

Treatment

Once bladder cancer is found, staging tests are performed to find out if the cancer has spread and, if so, to what parts of the body. Treatments for bladder cancer depend on the stage of the cancer. The stages of bladder cancer are as follows:

• Stage 0: cancer cells are found only on the surface of the inner lining of the bladder

• Stage 1: cancer cells are found deep in the inner lining of the bladder; no lymph nodes involved

• Stage 2: cancer cells have spread to the muscle of the bladder; no lymph nodes involved

• Stage 3: cancer cells have spread through the muscular wall of the bladder to the layer of tissue surrounding the bladder OR possibly to the reproductive organs including the prostate glands; no lymph nodes involved

• Stage 4: cancer cells extending outside the bladder to the wall of the abdomen or to the wall of the pelvis without lymph node involvement OR have spread to one or more lymph nodes and other parts of the body

Prevention

The following steps can reduce your risk of getting bladder cancer:

• Don't smoke or use tobacco products. If you do, quit.

• Avoid or minimize occupational exposure to certain chemicals; follow good work safety practices.

• Eat a diet rich in fruits and vegetables.

• Avoid excess intake of high fat or high cholesterol

• Minimize the use of phenacetin (a drug)

RESOURCES:

American Cancer Society
http://www.cancer.org

American Foundation for Urologic Diseases
http://www.auafoundation.org

American Urological Association
http://www.auanet.org

National Cancer Institute
http://www.cancer.gov

References

Abeloff MD, Armitage JO, Niederhuber JE, Kastan MB, Mckenna WG, eds. Clinical Oncology, 3rd ed. Philadelphia, PA: Churchill Livingstone, Elsevier; 2004.

Bladder cancer. American Cancer Society website. Available at: http://www.cancer.org/docroot/CRI/CRI_2_3x.asp?rnav=cridg&dt=44. Accessed March 6, 2006.

Bladder cancer. JAMA Patient Page. Journal of the American Medical Association website. Available at: http://jama.ama-assn.org/cgi/content/full/293/7/890. Accessed March 8, 2006.

Bladder cancer (PDQ): Treatment Patient Version. National Cancer Institute website. Available at: http://www.cancer.gov/cancertopics/pdq/treatment/bladder/Patient/allpages/print. Accessed March 8, 2006.

Walsh PC, ed. Campbell's Urology, 8th ed. Philadelphia, PA: Saunders, Elsevier; 2002.

What you need to know about bladder cancer. National Cancer Institute website. 2002. Available at: http://www.cancer.gov/cancerinfo/wyntk/bladder. Accessed March 6, 2006.